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These results closely mirrored clinical findings, which show that individuals with PCOS and obesity typically lose around 16.7 pounds after three months and 25.3 pounds after six months on low-dose Semaglutide

We dont have enough data right now, but certainly the COMPASS long-term data looking at psilocybin for treatment-resistant depression seems- you know, a single dose of 25mg of synthetic psilocybin in a controlled setting certainly was durable for most patients with an effect size, you know, at least as good, but probably better than like SSRIs and that type of thing

In humans, intravenous infusion of a somatostatin analog, octreotide, 30 min prior to carbohydrate meal (Hycal) significantly impairs insulin, GLP-1, and GIP secretion in both lean and obese women, yet post-heparin LPL activity (contributions from adipose, skeletal and cardiac tissue) is unchanged 1.5 h post-peak insulin in lean and obese women (Ranganath et al., 1999)

But with only 4% bioavailability, you are essentially paying for expensive diarrhea