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CLINICAL TRIAL EVIDENCE FOR DUAL GLP-1/GLUCAGON RAs AND TRIPLE AGONISTS IN MASH Survodutide Survodutide, a weekly dual GLP-1/GCG agonist, was assessed in a phase 2 dose-finding trial (NCT04771273) including 293 individuals with histologically confirmed MASH and fibrosis stages F1-F3 [46]

Any therapy that sustains high IGF-1 raises a theoretical concern about promoting the growth of existing or nascent tumors

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A prior pancreatitis diagnosis, medullary thyroid cancer family history, or inflammatory bowel disease may contraindicate semaglutide or require specialist oversight