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Macrophage depletion can reduce inflammatory cytokines and trigger adiponectin secretion from both SAT and VAT adipocytes, leading to the induction of preadipocyte differentiation in SAT, but not VAT

Common side effects include: Nausea (the most frequent side effect) Stomach pain or bloating Diarrhea or constipation Vomiting Heartburn or acid reflux Mitigating Side Effects: Side effects are typically most intense when you first start the medication or when the dose is increased

Clinical guidelines emphasize that patients on GLP-1 medications should prioritize protein to prevent muscle loss