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In general, mice of 816 weeks of age of both sexes were treated with 1 mg ml 1 doxycycline hyclate BioChemica (PanReac, A2951) in the drinking water (supplemented with 7.5% sucrose) for 7 d

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The effect of AOD-9604 on the underlying mechanisms of osteoarthritis was demonstrated by changes in the gross clinical examination as well as changes in the microscopic structure of the cartilage in the affected joints

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