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Indeed, the pharmacokinetic and pharmacodynamics of any drug taken by mouth should be appraised considering the role of the microbiota, as the varied efficacy of some chemotherapeutics such as 5-FU has been proven to directly depend on this host-microbiota metabolism (400)

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In proportion to the content of O 2 and H 2 O 2 , the content of the final product of lipid peroxidation, MDA, was 1.66- and 1.53-fold higher in the roots and leaves of As-treated seedlings than in the controls, respectively