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Tirzepatide onset: Some users report faster appetite suppression, with noticeable changes as early as the first week at starting dose
Data summarised in the Xenical 120 mg SmPC and in Cochrane reviews indicate that, on average, orlistat 120 mg produces approximately 2.53.5 kg more weight loss than placebo over 12 months, with a greater proportion of patients achieving clinically meaningful thresholds of 5% or 10% body weight loss
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They saw additional weight loss over the remaining 48 weeks at the full dose
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