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This scenario illustrates why most fatigue and nausea do not result from b12 deficiency

Crucially, this ROS surge actively drives pathology as a core hypoxic stress mediator, directly regulating inflammatory responses, cell death pathways, and autophagy via dysregulation of key signaling effectors

State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China 2

Which means dental visits could evolve beyond teeth into early health screening touchpoints