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Patients with previous use of any SGLT2i or GLP-1RA at any time before treatment initiation with empagliflozin or a GLP-1RA were not included in the analyses

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Astrogliosis is prevalent in the epilepsies, and interestingly a mouse forebrain neuron-specific knockout of SOD2 resulted in seizures, oxidative stress, and marked GFAP and vimentin gene upregulation, indicative of astrogliosis resulting from increased neuronal mtROS (Fulton et al., 2021)

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