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Rybelsus, another oral form of semaglutide, remains approved for type 2 diabetes, while oral Wegovy is indicated for weight management.
Clinicians should maintain perspective: the substantial metabolic benefits of tirzepatideincluding HbA1c reduction averaging 2.0-2.5% in type 2 diabetes trials (SURPASS) and weight loss of 15-20% in obesity trials (SURMOUNT)may confer overall cardiovascular benefit that outweighs any theoretical concerns about clotting risk, though this requires confirmation from long-term outcome studies
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Biomaterials 144 , 119129 (2017)
