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Frequency and Risk Factors Hypersensitivity reactions to vitamin B12 are rare but may be more likely with long-term or repeated injections, regardless of the chemical form or route of administration

This is primarily a result of the peptides ability to upregulate and activate VEGFR2, one of the more important receptors for VEGF

They enhance regulatory T-cell function, which is significant because defective T-cell regulation is a core driver of autoimmune thyroid destruction