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Acetyl-glutathione (S-acetyl-L-glutathione) adds an acetyl group that blocks the gamma-glutamyl bond, preventing premature breakdown while maintaining the ability to regenerate active glutathione once absorbed
To test the effect of this putative pseudo-substrate on CDK11 activity, we performed kinase assays using wild-type CDK11 p58 -cyclin L2-SAP30BP and complexes harbouring a C-terminal deletion in CDK11, removing the putative pseudo-substrate segment (CDK11 C), the phospho-mimetic CDK11 S752E mutation, and the non-phosphorylatable CDK11 S752A mutation (CDK11B p110 residue numbering is used for consistency
Studies have reported defective cholesterol metabolism in the brains of ALS patients and abnormal lipid droplet accumulation in astrocytes, particularly in regions like the motor cortex and spinal cord (Chaves-Filho et al., 2019)
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