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This pathway was recently defined more precisely, indicating that right vagal afferents that innervate the duodenum form part of an elaborate polysynaptic circuit involving neurons in the right ventromedial NTS, non-CGRP-expressing neurons in the dorsal lPBN and dopaminergic neurons in the substantia nigra [106]

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This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation