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The Aib (2aminoisobutyric acid) residue at the Nterminus improves resistance to enzymatic degradation, while modified amino acids such as D2naphthylalanine and Dphenylalanine enhance laboratory stability
The following occurred in the respective cases: sodium and chloride depletion fluid overload septicemia, or blood poisoning, in an individual with existing compromised liver function and portal hypertension While underlying conditions may have increased the risk of severe side effects or death in some cases, these findings suggest that coffee enemas are generally not safe
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