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A 2025 review in Cell highlighted the benefit of GLP-1 therapies on anti-inflammatory mechanisms involved in cardiovascular, kidney and liver conditions, and disorders like obstructive sleep apnea

According to the Cochrane Collaborations tool for assessing risk of bias, there was no major risk of bias in any study (Fig

The cardiovascular safety of this dose of semaglutide is currently being evaluated in the SELECT trial, where 17,500 individuals with obesity and established CVD are randomised to semaglutide or placebo for 2.5-5 years