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(2010) utilized IGF-1 and its analogs to investigate the relative contributions of PI3K/Akt versus MAPK/ERK signaling in IGF-1R-mediated cellular responses, demonstrating context-dependent pathway utilization across different cell types
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Another black box warning was given for suicidal thoughts and behavior, in the under-25 age range, and another warning was required for causing compulsive behaviors such as pathological gambling, binge eating, compulsive shopping, and hypersexuality
These effects can be particularly concerning for individuals who need to maintain a high level of alertness, such as those operating heavy machinery or driving
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