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In the context of acquired resistance, PDX models can be subjected to repeated drug exposure to mimic disease progression observed in patients transitioning from initial sensitivity to resistance
In the trials of these drug classes, tirzepatide (the SURMOUNT program) produced average weight loss roughly in the 15% to 21% range across doses at about 72 weeks, while semaglutide (the STEP program) produced around 15% at about 68 weeks
You have to keep moving, so some people might be awake until 2 or 3 in the morning. Some people with restless legs syndrome feel it every night
Big kudos to everyone working hard behind the scenes
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