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The saliva of the Gila monster creates a substance that looks very similar to the GLP-1 our body naturally makes, explains Andrea Traina, PharmD, obesity medical director for Novo Nordisk

In the Lira Pump study, they decreased basal insulin by 10%, but increased bolus by 15% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

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Medical College of Virginia