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Its main metabolizing enzymes include CYP3A4 and CYP3A5, and its disposition is also affected by P-gp transporters found in the liver [14]

ArticlePubMed 37

We all hit a plateau when we need to do something more aggressive beyond just cutting more calories, says Kopp

The strongest risk occurred within the first year of treatment That timing may suggest an association between the drug and the sudden onset of optic nerve injury, though a retrospective cohort design cannot establish a definite causation

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