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Avoid metabolic enzyme inducers drugs like rifampin may reduce effectiveness by speeding up drug clearance
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus (as Mounjaro) and, more recently, for chronic weight management (as Zepbound) in adults with obesity or overweight with weight-related comorbidities
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Metoclopramide and other prokinetic agents that accelerate gastric emptying may theoretically counteract some of tirzepatides therapeutic effects and should generally be avoided unless determined necessary by the prescribing provider
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