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Polyphenols can prevent ototoxicity of cisplatin by improving cellular antioxidant homeostasis, modulating signaling pathways, mitigating inflammatory responses, and ameliorating the disruption of cisplatins intra-auricular environment in a dose- and time-dependent manner (Maiuolo et al., 2022).Moreover, after studies of natural compounds with anti-tumor properties, polyphenols have emerged as strong chemotherapeutic sensitization candidates (Vladu et al., 2022
It has been approved by the FDA to treat visceral adiposity (excessive fat around the midsection) in HIV-infected patients with lipodystrophy [5]
Furthermore, GSTs catalyzed the conjugation of cinnamic acid with GSH in suspension cultured cells of legume species (Figure 1)
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