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While Wegovy can help lower blood sugar levels over time, it does not quickly lower blood sugar like insulin
Drug working concentrations and stock preparation were as follows: GLP-1MK-801 and MK-801 (both 50 M, dissolved in aCSF or magnesium-free aCSF), NMDA (100 M, dissolved in magnesium free aCSF), CNQX (10 M, dissolved in DMSO, Alomone Labs), picrotoxin (100 M, dissolved in DMSO)
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The mechanisms underlying mitochondrial dysfunction include excessive generation of mitochondrial ROS (mtROS), loss of mitochondrial membrane potential, release of (mtDNA into the cytoplasm, and dysregulation of mitochondrial dynamics such as fission and fusion (Monzel et al., 2023)
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