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Regarding direct metabolic effects, research indicates that these medications do not substantially increase basal metabolic rate

Weight Loss: The average percent weight loss from patients starting weight after these 17 months at the maintenance dose was: -15% weight loss from baseline body weight at 68 weeks at the 2.4mg dose -In a two year follow up study, those who continued to take semaglutide at the 2.4mg dose were able to maintain an average of 15.2% of their initial weight

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