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Medications most frequently associated with triggering or exacerbating RLS include: Antidepressants: A systematic review concluded that mirtazapine carries a high risk, while SSRIs, most SNRIs, and tricyclic antidepressants slightly increase the risk (Kolla et al., 2018)
Seiwerth S et al
Samanta, J
They change gastric emptying rate and transit time, which modifies the intestinal environment including local pH levels and nutrient availability
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