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Insulin-sensitizing drugs are the second-line treatment, with metformin being the most recommended therapeutic option, to improve peripheral insulin sensitivity in order to decrease insulin levels and, consequently, insulin-mediated stimulation of ovarian androgen secretion 17

Abstract Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function

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Other studies have reported effects on overall growth of the pancreas (as opposed to islet growth) or evidence of increased exocrine mitogenesis