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A Phase I trial of the small non-peptide GLP-1 receptor agonist danuglipron in 98 patients with type 2 diabetes found that it had a similar glucose-lowering ability as the clinically used GLP-1 receptor agonists and was well tolerated during the 4 week study period [43]
In type 2 diabetes, these hormones are greatly decreased and do not work as well to cause that insulin secretion
In vitro studies further demonstrate that GLP-1 analogs directly reduce human eosinophil activation as evidenced by decreased surface expression of CD69 and CD11b, and suppressed secretion of IL-4, IL-8, and IL-13 [70]
Case reports and clinical series document supplement induced odor in susceptible people
