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Tesamorelin adds visceral fat reduction (directly addressing the obesity component), improved body composition (supporting metabolic rate), and potential cardiovascular benefits through reduction of the inflammatory visceral fat depot
It requires energy, nutrients, and constant upkeep
Notably, SURMOUNT-2 specifically evaluated tirzepatide in individuals with type 2 diabetes, demonstrating superiority over both GLP-1 monotherapy and insulin-based regimens
The co-primary endpoints were the percentage change of weight reduction in the Tirzepatide 10mg and 15mg dose groups at week 72 and the percentage of participants achieving 5% body weight reduction at 72 weeks compared to placebo
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