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Modulates expression of collagen, decorin, elastin and matrix-metalloproteinase genes in dermal fibroblast cultures
Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations
When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases
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