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Gene ontology of genes in the NRF2 cistrome that were also upregulated by BDG exposure were enriched for the biological processes: response to oxidative stress, cell-cell adhesion, cytokine signaling, and glutathione metabolism ( Figure 3D and Supplementary Table 5B )
Vitamin B12 is mainly excreted from urine and bile
The hydroxylation at the asparaginyl residue blocks the interaction of the alpha subunits with coactivators and thus results in the inactivation of HIF
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