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Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)

As investigations continue to uncover its multifaceted impacts, IGF-1 LR3 is believed to hold promise as a significant tool for advancing our understanding of biology and addressing critical scientific challenges

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Conclusion The potential for GLP-1 RAs to serve as a therapeutic option in AS presents an exciting avenue for further exploration, particularly given the unmet need for treatments that slow the progression of kidney function decline in this patient population