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This contraindication stems from observations in rodent studies where tirzepatide and similar GLP-1 receptor agonists caused thyroid C-cell tumors at clinically relevant exposures
On December 19, 2025, Eli Lilly announced that retatrutide produced 28.7% body weight loss in the Phase 3 TRIUMPH-4 trial
The article suggests these may correlate with how someone responds early and how soon a provider revisits the plan, though it cites no studies for those associations
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