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Alan Rogol, a pediatric endocrinologist at Riley Hospital for Children in Indianapolis

Oxidative stress, therefore, interacts with these hallmarks of aging rather than acting as an isolated driver of reproductive aging

Because of its presence in blood and tissue fluids, it is considered a physiologic carrier of copper, with roles in signaling and tissue maintenance that remain under active investigation

The protein thioredoxin, together with TXNRD1 (or TXNRD3), NADPH, and FAD, constitute the thioredoxin antioxidant system involved in the reduction of antioxidant enzymes (e.g., peroxiredoxins, methionine sulfoxide reductases, and ribonucleotide reductase) and of many oxidation/reduction (redox)-sensitive signaling proteins (9)