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52 Atrial fibrillation (AF) is not only a complication of various cardiovascular diseases but also significantly increases the risk of cardiovascular events
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People with stomach and intestinal conditions such as celiac disease and Crohns disease may struggle to absorb enough B12 from their food
The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]
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