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The trade-off is pharmacokinetic: oral delivery subjects the peptide to stomach acid (pH roughly 1.5-2.0 fasting) and proteolytic enzymes including pepsin and pancreatic proteases before any absorption can occur
Sometimes a needle nicks one on the way in or out, even when the injection is done correctly
The ketogenic diet (KD) is a regimen that severely restricts carbohydrates and induces lipid metabolism and ketone body (KB) synthesis by mimicking a fasting state (108)
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