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That average weight loss rose to more than 15% by week 48 on the heaviest dose of ecnoglutide, researchers reported in updated trial results presented Saturday at the American Diabetes Associations annual meeting in Chicago

Specifically, researchers found a reduction in GABA levels in the parieto-occipital cortex and the temporal cortex (regions in the brain)

(accessed August 03, 2026)

However, when patients follow the administration protocol correctly, weight loss outcomes are broadly comparable approximately 1415% over the treatment period for both forms