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Difficulty Achieving Long-Term Weight Loss Individuals who have made consistent efforts with diet and physical activity but continue to struggle with sustained weight management may benefit from medications that target appetite regulation
It also affects your brain and central nervous system pathways that regulate digestion, potentially contributing to altered bowel function beyond the direct GI tract effects
The headline number depends entirely on which estimand you quote, and the two figures are not interchangeable: 20.4% mean body-weight change at week 68 with CagriSema vs 3.0% with placebo (estimated difference 17.3 percentage points
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