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In SURPASS trials, patients receiving tirzepatide with metformin experienced mean weight loss ranging from 7.6 kg to 12.9 kg depending on tirzepatide dose, compared to baseline
If bloating is your only significant side effect and weight loss is progressing, the risk-benefit calculation may favor persistence with management strategies
The field needs further comparison investigations, especially on small sequence-driven changes in binding behavior and biological response
Journal of Alternative Complementary Medicine
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