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As these substances are released and processed by the liver and gut for elimination, it can sometimes create a temporary state of overload
J Clin Invest 122(4):13161338
However, stores can run low due to a number of factors, including a genetic inability to produce sufficient amounts
Results: Examination of the Reactome XENOBIOTICS pathway (R-HSA-211981) shows that many of the P450 cytochromes expressed by primary hepatocytes (CYP2E1, CYP2C8, CYP2C9, CYP3A4, CYP2A6) are nearly completely absent in all cell lines
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