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Oral semaglutide drops is a compounded suspension designed to be applied under the tongue
(PubMed) Petersen JM, Parker SE, Crider KS, Tinker SC, Mitchell AA, Werler MM
The strongest evidence comes from one study that followed adults with obesity or overweight
Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]
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