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Earlier intervention, when follicles are miniaturized but not gone, is where the evidence is most plausible
The flagship trial STEP-1 (published in NEJM , 2021) found a mean weight reduction of ~14.9% of body weight with semaglutide 2.4 mg vs ~2.4% with placebo over 68 weeks ( [12] )
Individuals with liver conditions, metabolic disorders, or those undergoing regular IV glutathione therapy should be especially cautious
This broadening application reflects a growing understanding of GLP-1s diverse physiological effects
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