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Most protocols are cycled: 5-6 months on, 1-2 months off to allow the pituitary to reset
It also implies that a user can take their dose at any time of day, regardless of their desired health outcome
Separate studies demonstrated anti-anxiety effects in rats at remarkably low doses (0.5 mg/kg), with effects appearing within 12 minutes and including increased exploration of open and lighted spaces, a standard measure of reduced anxiety in rodent models
Weeks 6 to 12: Strength return and tolerance of progressive loading
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