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This start low and go slow approach helps minimize side effects

EMBO J 16:48064816 Wingate VPM, Lawton MA, Lamb ChJ (1988) Glutathione causes a massive and selective induction of plant defense genes

A recent study has shown that argininosuccinate synthase 1 (ASS1) and spermidine/spermine N1-acetyltransferase (SAT1), the central enzymes for arginine metabolism, are hypermethylated in cisplatin-resistant bladder cancer cells (Yeon et al., 2018)