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This timeline underscores the importance of monitoring from the very start of treatment, not waiting until symptoms appear
The main reason to be cautious with a 16-week plan is that there is no clinical subcutaneous evidence to guide the extension
The guidance emphasized post-marketing surveillance informed by pre-marketing safety signals, moving away from a rigid one-size-fits-all model
That "days 45" figure is the closest thing to an onset signal in the literature, and it is repeatedly miscast online as a human timeline
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