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Inflammation and Hormones: GLP-1 also seems to play a role in regulating inflammation and hormones like cortisol, which are known to be linked to mood
Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 2a genetic neurodegenerative disorder due to a CAG repeat expansion mutation in the ATXN2 gene coding for the protein ataxin-2 63 has been associated to oxidative stress, in particular due to alterations in the enzymatic activity of antioxidant enzymes including GSTs 64
While a dedicated cardiovascular outcomes trial has not yet been completed (the gold standard for proving cardiovascular protection), the available metabolic data strongly suggests meaningful cardioprotection
What stood out was that these benefits: Appeared across a wide range of body sizes Were only partly explained by weight loss And persisted even when changes in body fat were modest Follow-up analyses confirmed that improvements in cardiovascular outcomes could not be fully attributed to changes in body weight or waist circumference alone
