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While fruit does contain fructose, the fibre, water, and nutrient content of whole fruit means it affects blood glucose differently than refined sugars or fruit juice

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Translating the pharmacology of dual GLP-1/GIP agonists into actionable preclinical data requires tools capable of detecting receptor engagement with cellular and spatial resolution , challenging because GLP-1R and GIPR are low-abundance membrane proteins, and no reliable commercial antibody exists for GIPR detection in primary tissues