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It also paves the way to fabricate a turn-on or turn-off fluorescent nanobiosensor for relevant biomarkers in cancer cells, presenting potential nanotheranostic applications in biological detection and clinical diagnosis
Mechanistic validation further confirmed downregulated expression of Nrf2, HO-1, and GPX4 in CLP mice, establishing a direct link between glutathione dysregulation and neuronal apoptosis
Sara Pittman , Emma Dixon, and Robin Couch
Br J Clin Pharmacol 59:491494 Bailey WJ, Holder D, Patel H, Devlin P, Gonzalez RJ, Hamilton V, Muniappa N, Hamlin DM, Thomas CE, Sistare FD, Glaab WE (2012) A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate dioxygenase
