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To confirm whether the reduction in heat sensitivity after glucose application was due to the systemic release of GLP-1, we intraperitoneally administered 10 g/kg GLP-1(736), one of the two primary biologically active forms of secreted GLP-1
It takes about two minutes per injection
We are thankful to Dr Jean Kim and the Human Stem Cell Core at Baylor College of Medicine for mediating the cell transfer, Dr Tobias Dick for Grx1-roGFP2 plasmid, and Drs Vsevolod Belousov, Luke Lavis, and Catherine Goodman for thoughtful discussions
It's particularly important within the organs that are responsible for cleansing our bodies, especially the liver and kidneys, but also the lungs and intestines
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