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Several research teams have targeted GSH synthesis inhibitors as potential therapeutic agents
The two therapies work in tandem: one purifies at the cellular level, the other clears the pathways that carry waste away
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Conversion of calcidiol to its biologically active form, calcitriol, occurs through the activity of a specific 25-hydroxyvitamin D 3 1--hydroxylase (commonly just called 1--hydroxylase) present in the inner mitochondrial membrane of cells of the proximal convoluted tubules of the kidneys, and in several extrarenal sites such as in keratinocytes, macrophages, and placenta
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