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BSO treatment promoted an early induction of the senescence zone in wild-type nodules (Figures 8C,D) concomitant with an increase in the expression of the senescence-associated genes Cyp15a and TPP (Serova et al., 2017
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This finding suggests that host-microbiome interactions in skin diseases require omics integrated analyses in order to gain insights into their underlying molecular mechanisms, as we will illustrate more in detail in the following sections of this review
AHK-Cus small molecular weight (approximately 400 Da) falls within the range where meaningful transdermal penetration is pharmacologically plausible, particularly on the scalp where the stratum corneum is thinner than on most body surfaces and where hair follicle openings provide additional transappendageal absorption routes
