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[] When EDTA was first introduced clinically, it was in the form of its sodium salt and known as Na 2 EDTA

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Chemical conjugation of epothilone with glutathione was studied, displaying a noticeable increasing of its anticancer activity towards various tumor cells [75], however, using several chemicals as cross-linkers for orienting the reaction, and checking the progress of reaction, and extra steps for purifying the conjugate is the major challenge