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In summary, nanoparticles can not only exert antitumor activity by regulating TAMs, NK cells, DCs, TANs, MDSCs, and T cells in the TME, but also simultaneously regulate two or more immune cells to exert antitumor immunity, such as simultaneously regulating NK cells and T cells, regulating TAMs and T cells, regulating DCs and T cells, as well as nanoparticles that simultaneously regulate multiple immune cells
Immune response regulation in the tumor microenvironment by hypoxia
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